Eric Dane, the celebrated actor best known for his roles on “Grey’s Anatomy” and “Euphoria” and who later in life became advocate for ALS awareness, died Thursday. He was 53.

His representatives said Dane died from amyotrophic lateral sclerosis, known also as Lou Gehrig’s disease, less than a year after he announced his diagnosis.

“He spent his final days surrounded by dear friends, his devoted wife, and his two beautiful daughters, Billie and Georgia, who were the center of his world,” said a statement that requested privacy for his family. “Throughout his journey with ALS, Eric became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight. He will be deeply missed, and lovingly remembered always. Eric adored his fans and is forever grateful for the outpouring of love and support he’s received.”

Dane developed a devoted fanbase when his big break arrived in the mid-2000s: He was cast as Dr. Mark Sloan, aka McSteamy, on the ABC medical drama “Grey’s Anatomy,” a role he would play from 2006 until 2012 and reprise in 2021. In 2019, he did a complete 180 from the charming McSteamy and became the troubled Cal Jacobs in HBO’s provocative drama “Euphoria,” a role he continued in up until his death.

Dane developed a devoted fanbase when his big break arrived in the mid-2000s: He was cast as Dr. Mark Sloan, aka McSteamy, on the ABC medical drama “Grey’s Anatomy,” a role he would play from 2006 until 2012 and reprise in 2021. In 2019, he did a complete 180 from the charming McSteamy and became the troubled Cal Jacobs in HBO’s provocative drama “Euphoria,” a role he continued in up until his death.

Dane was born on Nov. 9, 1972 and raised in Northern California. His father, a Navy man, died of a gunshot wound when he was 7. After high school, he moved to Los Angeles to pursue acting, landing guest roles on shows like “Saved by the Bell,” “Married...With Children,” “Charmed” and “X-Men: the Last Stand,” and one season of the short-lived medical drama “Gideon’s Crossing.”

A memoir by Dane is scheduled to be published in late 2026. “Book of Days: A Memoir in Moments” will be released by Maria Shriver’s The Open Field, a Penguin Random House imprint. According to Open Field, Dane will look back upon key moments in his life, from his first day at work on “Grey’s Anatomy” to the births of his two daughters and learning that he had ALS.

“I want to capture the moments that shaped me — the beautiful days, the hard ones, the ones I never took for granted — so that if nothing else, people who read it will remember what it means to live with heart,” Dane said in a statement around the book’s announcement. “If sharing this helps someone find meaning in their own days, then my story is worth telling.”

Dane is survived by his wife, actor Rebecca Gayheart, and their two teen daughters, Billie Beatrice and Georgia Geraldine. Gayheart and Dane wed in 2004 and separated in September 2017. Gayheart filed for divorce in 2018, but later filed to dismiss the petition. In a December essay for New York magazine’s The Cut reflecting on Dane’s diagnosis, Gayheart called their dynamic “a very complicated relationship, one that’s confusing for people.” She said they never got a divorce, but dated other people and lived separately.

“Our love may not be romantic, but it’s a familial love,” she said. “Eric knows that I am always going to want the best for him. That I’m going to do my best to do right by him. And I know he would do the same for me. So whatever I can do or however I can show up to make this journey better for him or easier for him, I want to do that.”