ITALY (AP) - Five years after “Joker” won the top prize at the Venice Film Festival, filmmaker Todd Phillips is returning with the sequel. “Joker: Folie à Deux” will play in competition with 20 other titles, festival organizers said Tuesday.

The highly anticipated follow-up to the blockbuster comic book film stars Joaquin Phoenix as the mentally ill Arthur Fleck and Lady Gaga as Harley Quinn.

The lineup for the 81st edition of the festival, unveiled early Tuesday, also includes new films starring Brad Pitt, George Clooney, Angelina Jolie, Nicole Kidman, Daniel Craig and Jude Law.

Among the films playing alongside “Joker 2” in competition are Pablo Larraín’s Maria Callas film “Maria,” starring Jolie; Walter Salles’ “I’m Still Here"; the erotic thriller “Babygirl” starring Kidman and Harris Dickinson from filmmaker Halina Reijn; Luca Guadagnino’s William S. Burrough’s adaptation “Queer,” with Craig and Jason Schwartzman; and Pedro Almodóvar’s first English-language film, “The Room Next Door,” starring Julianne Moore and Tilda Swinton. Set in New England, the filmmaker has said it’s about an imperfect mother and a resentful daughter.

“The Order,” Justin Kurzel’s 80s-set crime thriller about the white supremacist group starring Law as an FBI agent, Nicholas Hoult and Jurnee Smollett, will also be in competition, as will Brady Corbet’s “The Brutalist,” with Adrien Brody, Guy Pearce, Felicity Jones and Joe Alwyn. Shot on 70mm, the 215-minute epic is about a Hungarian Auschwitz survivor who goes to the United States.

Pitt and Clooney will reunite in Jon Watts’ “Wolfs,” an adrenaline packed action-comedy about a few fixers that will screen out of competition.

Several interesting films playing in the horizons extra section include “September 5,” about the live television coverage of the Munich Olympics, starring Peter Sarsgaard; John Swab’s “King Ivory,” with Ben Foster and James Badge Dale; and Alex Ross Perry’s film about Stephen Malkmus’ California rock band Pavement.

Venice will also screen Peter Weir’s 2003 epic “Master and Commander: The Far Side of the World,” in conjunction with his lifetime achievement award.

Seven episodes of Alfonso Cuarón’s psychological thriller series “Disclaimer” will also premiere at the festival. The AppleTV+ show is based on a novel about a documentary journalist and a secret she’s been keeping. It stars Cate Blanchett and Kevin Kline and will debut on the streamer in October.

Among the nonfiction titles playing out of competition are Kevin Macdonald and Sam Rice-Edwards’ “One to One: John & Yoko,” which reconstructs the New York years of the Beatle and his wife; Errol Morris’ “Separated,” about the separation of immigrant children from their parents in the U.S; Anastasia Trofimova’s “Russians at War”; Göran Hugo Olsson’s “Israel Palestine on Swedish TV 1958-1989”; “Riefenstahl,” about the German propagandist; And another Beatles-focused doc, “The Things We Said Today,” a time capsule of their arrival in New York and first concert at Shea Stadium.

Last year’s festival took place amid the actors’ strike. Although some attended under interim agreements, like Adam Driver and Penelope Cruz for “Ferrari” and “Priscilla” stars Cailee Spaeny and Jacob Elordi, the festival was lacking its usual, consistent supply of star power. But its awards season influence remained strong: Seven Venice world premieres went on to get 24 Oscar nominations and five wins: Four for “Poor Things” and one for Wes Anderson’s “The Wonderful Story of Henry Sugar.”

Venice is a significant launching ground for awards hopefuls and the first major stop of a busy fall film festival season, with Toronto, Telluride and the New York Film Festivals close behind.

The 81st edition kicks off on Aug. 28, with the world premiere of Tim Burton’s “Beetlejuice, Beetlejuice.” All of the main cast, including Michael Keaton, are expected to grace the red carpet. The Venice Film Festival runs through Sept. 7.