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Manila Bulletin devider Philippines devider National devider PH COVID-19 vaccine mix-and-match trial may start in mid-September —DOST

PH COVID-19 vaccine mix-and-match trial may start in mid-September —DOST

Published Aug 20, 2021 12:00 am

The Department of Science and Technology (DOST) said Thursday night, Aug. 19, that Philippines’ study on the safety and efficacy of mixing and matching five coronavirus disease (COVID-19) vaccines is likely to begin in mid-September.

(Photo by Robyn Beck/AFP/FILE PHOTO/MANILA BULLETIN)

DOST Undersecretary for Research and Development Dr. Rowena Cristina L. Guevara, who heads the Task Group on Vaccine Evaluation and Selection (TG-VES), said the actual trial could be expected within this month.

Related story: https://mb.com.ph/2021/08/12/preparations-underway-for-ph-covid-19-vaccine-mix-and-match-trial/

“Target date for first patient is mid- September,” she said, citing that the trial will involve 3,000 participants aged 18 and above.

Guevara said the participants will most likely come from the National Capital Region (NCR) and belong to A1 to A4 priority groups under the country’s COVID-19 inoculation program.

The Philippine Society for Allergy, Asthma, and Immunology (PSAAI) project team, led by Dr. Michelle De Vera is set to look at the safety and immunogenicity of interchanging vaccine brands.

Five vaccine brands such as Sinovac, Sputnik V, AstraZeneca, Pfizer and Moderna will be used for the 18 month-long PSAAI study, which was initially targeted to start by June this year.

Guevara said the project team is currently revising the protocol based on the comments of the Single Joint Research Ethics Board (SJREB) and Institutional Review Boards (IRBs).

“They are also finalizing the final quotations for the lab assays and insurance. The project team is waiting for the endorsement from DOH to LGUs and the requested vaccine doses,” she said.

“For the sites, the project team is coordinating with candidate sites,” she added.

The DOST disclosed that the study will be conducted in eight proposed sites: Antipolo or Marikina City, Manila, Pasig City, Makati or Pasay City, Muntinlupa City, Quezon City, Cebu and Davao.

Apart from determining the safety and immunogenicity of interchanging vaccine brands to complete COVID-19 vaccine series, the PISAAI study also seeks to determine the efficacy of the booster doses,

It aims to determine if the high-risk population who already completed the dosing regimen of the Sinovac vaccine would elicit a better immune response after the immunization of a booster dose from a different vaccine platform or brand.

Related story: https://mb.com.ph/2021/06/03/mix-and-match-what-you-need-to-know-about-phs-study-on-covid-19-vaccine-mixing-matching/

Related Tags

rowena guevara MIX AND MATCH VACCINE STUDY Task Group on Vaccine Evaluation and Selection COVID-19 vaccines DOST
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